Saint Domnica came from Carthage to Constantinople in the time of the holy Emperor Theodosius the Great. Here she was baptized by Patriarch Nectarius and entered a women's monastery.
Through strict and prolonged ascetic effort she attained to high spiritual perfection. The saint healed the sick, demonstrated power over the natural elements, and predicted the future. By her miracles the saint moved inhabitants of the capital towards concerns about life eternal and the soul. Adorned by virtues, the saint departed this life a spotless virgin in her old age.