约安出生于约阿尼纳，皇帝毕罗斯曾经定都于此。当约安的贫穷的父母都去世后，他来到了君士坦丁堡，继续以原来从事的手工艺为生。此前不久，土耳其人包围了君士坦丁堡，许多基督徒出于恐惧都否认了基督改信伊斯兰教。圣约安的作坊就在这些皈依伊斯兰教的人当中。年轻的约安越是对基督充满爱，他也就越公开地在这些叛教者面前表白自己的基督信仰。约安开始同他们就信仰问题进行争论，最后约安斥责他们背叛基督。这些人将约安带到了法官面前，作假证指控约安，声称约安早先信仰伊斯兰较，现在又皈依了基督教。之后约安遭到了毒打，并被投入到监狱中。第二天就是复活节，他们又将约安带出去毒打，但是约安却高声歌唱：“基督从死里复活了！”约安勇敢地对他的施刑者说：“任凭你们作好了，以使我能够尽快地从这短暂的世间走向永生。我是基督的仆人，我追随基督，为基督而死，这样我将与他一起同生！”之后，约安被绑上铁链，被带到焚烧处。看到为他准备的熊熊大火，约安立即飞奔到那里，跃入到大火中。施刑者看到约安喜悦于受火刑，于是将约安从火中拉了出来，并将其宣判，进行斩首。约安被斩首之后，他们将约安的头和身体投入到火中。后来，一些基督徒来到刑场，收敛了约安的遗骨，并送到君士坦丁堡的大教堂中。由此，约阿尼纳的约安荣耀殉道，得到了天国荣耀的冠冕。他殉道的时间是公元 
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