在康斯坦蒂乌斯在位期间，瓦西里饱经了亚兰人的折磨。当时，他在安西拉忠心地牧羊信众，对东正教投入了极大的热忱，并广为人知。在叛教者犹利安继位之后，开始了对基督徒进行迫害。因为当时瓦西里公开地揭穿了信仰上的错谬，并增强信众的信仰，由此，他被投入到了监狱。当犹利安来到安西拉时，瓦西里被带到了他的面前。犹利安试图说服瓦西里放弃基督信仰，并许诺要给他荣誉和财富。瓦西里回答犹利安说：“我所相信的基督，赐给你在世上的王国，但是你却背叛了他；因此，他将会收回你的王位。你在八岁时险造杀戮，但是你却获得了上帝的拯救，难道你不觉得羞愧吗？因此，你的王位将难以久享，你的肉身在受尽苦楚魂飞魄散之后，尸首也不能入土为安。”犹利安大怒，下令每天从他的身上剥下七条皮肤来。就这样，瓦西里被施以酷刑好几天的时间。当他被带到犹利安面前时，瓦西里用从他身上剥下的“皮带”向犹利安仍去，对他说：“犹利安，接着！如果你觉得我的皮、我的肉是甜美的，就请吃下吧！但是对我来说基督才是生命。”这事件传遍了整个城市，犹利安出于羞愧而离开了安西拉，返回了安提约希亚。他们继续对瓦西里施以酷刑，将他放在烧红的铁块上，直到被折磨而死为止。当时是公元363年。 
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