圣玛喀里是埃及人，也是大圣安托尼的同代人，只是比他年轻。玛喀里的父亲是一名司祭。玛喀里曾奉父母之命娶妻。然而妻子不久就去世了，他便引退到了旷野之中，在那里，为了追求天国，修行了六十年，进行内在和外在的劳作和争战。有人曾问他：“你为什么进食不进食都这样消瘦呢？”他回答说：“因为对上帝的敬畏。”玛喀里洗净了自己的思想，将邪念彻底除去；洁净了自己的心，将恶意彻底清除。因此，上帝赐予他丰厚的施行奇迹的恩典，甚至可以使坟墓中的死人复活。他的谦卑使民众和魔鬼都为之惊叹。有一次魔鬼对他说：“我只有一件事不能战胜你。既不是斋戒——因为我从不吃喝；也不是守夜——因为我从不睡觉。”“那究竟是什么？”玛喀里问道。“是你的谦卑，”魔鬼回答说。玛喀里经常对他的门徒帕弗努提说：“不要论断别人就能得救。”玛喀里居世九十七年。他离世前九天，圣安托尼和圣帕霍弥从另一个世界向他显现，告诉他，他将在9天后离世。去世前，他还在神视中看见，赫儒文天使向他展示蒙福的天界，赞誉他的功德，并对他说，自己被派遣来将他的灵魂接到天国。圣玛喀里于公元390年进入基督永恒的国度。 
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