依西多尔是日尔曼人。来到罗斯托夫之后被东正教信仰迷住；他在教堂中领取神圣的圣体血，同时过着一种艰难的修行生活，得以“圣愚”的称呼。他身穿破旧的衣服走来走去，佯装成疯子在整个白日教导别人，而在晚间则进行祷告。他晚间栖身的地方只不过是用树枝和泥土搭成的草屋。这位圣人在世时以及去世后行了多次伟大、令人敬畏的奇迹。一个商人在航海时从船上掉下，此时，依西多尔出现，竟然行走在海面上将这个商人带到海岸。有一次，罗斯托夫的王子的仆人在依西多尔要求一杯水的时候拒绝了他的要求，并将他赶出门外，之后，他们所有的容器中的葡萄酒全部是空空的。依西多尔于公元1484年5月14日在他的草屋中去世，当时，整个罗斯托夫都闻到了一股香气。那个依西多尔曾经挽救过生命的商人在依西多尔曾经居住过的草屋的原址上为他建立了一座教堂。 
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