从年轻时起，德奥多西就避开言笑，一心专注上帝的旨意，并恒切进行祷告，由此，他经常遭到母亲的责备，特别是有一天，他的母亲看到了在他赤裸的身体上束上了一条铁带，使得鲜血染红了衣服。德奥多西曾经在圣经上看到有关主所说的一句话：“爱父母过于爱我的，不配作我的门徒”（玛特泰福音／太／玛10：37），之后他就离开了父母，来到了基督洞穴修道院拜见可敬的安托尼。安托尼收留了他，不久之后德奥多西接受了剪发礼成为一名修士。德奥多西的母亲找到了他，并要求他回家，他拒绝了母亲的请求，同时还说服了母亲，使她进入了一座女修道院。德奥多西因其苦行、谦卑以及善良而超越其他所有修士，深受安托尼的喜爱，并立他为修道院院长。在他担任修道院院长期间，修道院里的兄弟们之间的关系大大增进，同时建立了庵室，并全面引进了斯督迪修道院的诫规。上帝赋予了德奥多西丰盛的恩典，因为他的忠贞、恒切祷告、爱人如己，由此，这位上帝的仆人拥有很大的能力战胜不洁净之灵、医治病人，并能洞察人的命运。德奥多西同圣安托尼一起被认为是俄罗斯修道生活的奠基人。德奥多西于公元1047年安息主怀。他的圣髑能够治愈疾病，他的圣髑同圣安托尼的圣髑同被安放在一起。 
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