在埃及国王托勒密斯·费拉德尔夫斯在位期间，西麦翁被选为著名的“七十士”之一，这“七十士”被委以重任将希伯来文的《圣经》翻译成希腊文。西麦翁工作非常认真、负责，但是，在他翻译《伊撒依亚书》的时候读到以下的预言：“必有童女怀孕生子” （伊撒依亚书／赛／依7：14），他对这句话感到非常困惑，于是拿刀要将“童女”刮掉，用“年轻女子”取而代之并据此翻译成希腊文。然而，这时，一位上帝的天使向西麦翁显现，并制止他这样作，告诉他这预言是真实的，原文并没有错误，这是正确的。天使还告诉他说，他本人将确知此事，因为根据上帝的意旨，在未见童女生育弥赛亚之前他不会去世。听到来自天国的声音，西麦翁非常喜悦，他没有改动预言，并感谢上帝赐给他这样的福分，配得活着亲眼目睹被预言的这位。当童女玛利亚将圣婴带到耶路撒冷圣殿的时候，年迈且“如天鹅般雪白”的西麦翁受到了圣灵的启示，他疾速进入圣殿之中，在那里，凭着如同光环般笼罩在母子二人头上的光，西麦翁认出了他们。喜乐的西麦翁用手接过圣婴，祈祷上帝释放他离开此世说：“主啊！如今可以照你的话，释放仆人安然去世。因为我的眼睛已经看见你的救恩”（路喀福音／路加2：29－30）。法内力的女儿，女先知安纳也在圣殿中。她也认出了弥赛亚，并向众人宣告他的临到。那时候，安纳84岁，西麦翁在不久后离世。这位正义的长老西麦翁被视为儿童的保护者。 
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