伊撒依亚于公元5－6世纪在埃及的斯切特修行。在《圣瓦尔萨努斐和约安》（249个回答以及其他）一书中曾提到过他，认为他是一个拥有特别神圣的人。伊撒依亚为修士和隐士们书写了许多指导性的书。遗留下来的伊撒依亚的作品很少，其中许多都被穆斯林人毁坏了。圣伊撒依亚说：“思想在从懒惰的睡眠中清醒过来之前同魔鬼住在一起。”“一切善工的花冠在于：人将他的一切希望寄托于上帝；他一旦在上帝那里得到倚靠，就会全心全意帮助所有人；为所有人充满同情心，在上帝面前哭泣，请求他的帮助和怜悯。”对一个人来说，一个罪被赦免的标记是什么呢？“罪被赦免的标记是：罪不再在你的心中产生任何活动，你已经深深地忘记了这个罪，在谈到类似的罪时，你不会对这罪从产生任何倾向，而是认为这罪对你来说完全是陌生的东西。这就是罪完全被赦免的标记。”一个人如果在他心中隐藏着对他旁人的恶意以及报复的想法，那么对他来说祷告和修行都是徒劳的。“竭尽全力注视自己，这样，在你口中说的与你心中想的就不会完全是两样。”“善工的花冠是爱；欲望的花冠是人的罪的辩护。” 
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