当异端邪说的拥护者狄奥斯科鲁斯为亚历山大里亚牧首时，普若特里是亚历山大里亚的一名司祭。狄奥斯科鲁斯是基督一性论派的领导之一，基督一性论派认为，基督只有一性（人性），不具有两性（人性和神性）。玛尔基安和普鲁谢里亚是当时的皇帝和皇后。这位虔诚的圣人普若特里站起来反对狄奥斯科鲁斯，由此他也遭受了不少磨难。后来，第四次普世大公会议（公元451年，卡尔西顿）召开了，会上基督一性论遭到了谴责，狄奥斯科鲁斯被免去牧首职务，并被流放。普若特里这位真正的信仰上帝的圣人被选为牧首。他用热情和爱管理教会，成为基督真正的追随者。不管怎样，狄奥斯科鲁斯的追随者并不想在亚历山大里亚停止制造混乱。在发生了一次血腥事件的时候，普若特里离开了亚历山大里亚，打算暂时避一避。先知伊撒依亚在路上向他显现，对他说：“返回亚历山大里亚，我正在等着你，将你带走。”普若特里返回了亚历山大里亚，走进了教堂。获悉此事，异端暴徒们立即闯入教堂，抓住了普若特里，并用刀子在他身上乱戳。一同遭难的还有其他六名基督徒。由此，基督徒的好牧人普若特里为维护正教信仰于公元457年以殉道换取了那永恒的冠冕。 
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