圣玛喀里出生于亚历山大里亚，起初，他是一个水果商。40岁时，玛喀里接受了浸礼，并随即隐退修行。起初，他同大圣玛喀里同是圣安托尼的门徒。后来，他成了塞尔斯修道院院长。这座修道院位于尼特里亚和斯基特之间。他比大玛喀里年轻，也比他长寿，住世逾百岁。魔鬼诱惑他，这使他感到非常苦恼，尤其苦于虚荣的诱惑。为此，玛喀里用最艰苦的劳作和不间断的祈祷来使自己谦卑，使己心恒常朝拜于上帝前。有一次，一名修士看见他往篮子里装满沙子，将其运到山上，然后将沙子倒空。这位修士感到十分惊异，问道：“您在做什么？”他回答说：“我在折磨折磨我的家伙（即魔鬼）。”玛喀里于公元393年安息主怀。 
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